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焦虑抑制

焦虑抑制（也称为抗焦虑或微弱镇静）[1] 在医学上被认为是部分或完全抑制一个人感受焦虑、普遍不安以及心理和生理紧张的消极感觉的能力哦。[2] 体验这种效应可能会减少与焦虑相关的行为，比如坐立不安、肌肉紧张、[3] 反刍思维和惊恐发作呢。完全的焦虑抑制可以让人产生极度平静和放松的感觉；不过嘛，当伴随其他效应如去抑制或镇静时，也可能导致不良后果哟。

它最常在中等（Common）剂量的抗焦虑化合物影响下产生，这些化合物主要包括GABA能抑制剂，[4][5] 比如苯二氮卓类物质、[6] 酒精、[7] GHB[8] 和加巴喷丁类物质[9]。然而，它也可能在很多其他种类的药理学类别的药物影响下以较小的程度发生，包括但不限于大麻类物质、[10] 解离剂、[11] SSRI和阿片类药物呢。

目录

医疗用途

  • 地西泮 (Diazepam)：成人：严重急性焦虑或激越：10 mg 静脉或肌肉注射。[12]

体验报告

在我们的体验索引中，描述此效应的轶事报告包括：

  • Experience: 36mg 4-AcO-DiPT - Truly, one for the psychedelic animals among us
  • Experience: 660ug LSD - First bad trip
  • Experience:100 mg- Actually Lifechanging
  • Experience:120µg LSD - First Bad Acid Trip, Psychosis
  • Experience:150mg MDMA + 20mg 2C-B - I designed it this way myself
  • Experience:20mg (insufflated) - permanent all-encompassing states of unity and interconnectedness_-_permanent_all-encompassing_states_of_unity_and_interconnectedness.md)
  • Experience:20mg Etizolam - Smoking Etizolam
  • Experience:225mg Pregabalin +Cannabis -Bliss and Serenity; a hedonistic evening
  • Experience:25mg 2C-B - Hard raving at home
  • Experience:25mg Quetiapine - Nice buzz
  • Experience:260 mg Ketamine (insufflated) - Lost in Paisley_-_Lost_in_Paisley.md)
  • Experience:2C-P (approx. 35mg) - Asymmetrical Terror and the Geometric Sea_-_Asymmetrical_Terror_and_the_Geometric_Sea.md)
  • Experience:2mg 25C-NBOMe - Experimental trip to test personal limits of NBOMes
  • Experience:2mg Etizolam - Here be dragons
  • Experience:3 bowls of cannabis indica - I wrote down unintelligible gibberish
  • Experience:3-MMC: Weak substitute? No way!
  • Experience:3.5g psilocybe cubensis - Relinquishing of Material Chains/Fear and Desolation
  • Experience:300mg DXM + 25mg DMT + Cannabis - A crazy night
  • Experience:300ug LSD - Profound religious experience
  • Experience:300µg LSD - Togetherness and the Silent Dusk
  • Experience:3mg Etizolam - A Comedown Drug
  • Experience:40mg Zolpidem / 20mg Diazepam - Please Don't Do This
  • Experience:60mg 4-AcO-DMT Nonstop Quasi-Orgasmic Objectless Euphoria
  • Experience:60mg Zolpidem - A Delirious Adventure
  • Experience:70mg Lisdexamfetamine (oral) - My first stimulant experience_-_My_first_stimulant_experience.md)
  • Experience:7500mg - Analysis of gabapentin
  • Experience:800 seeds LSA - My First Trip Ever
  • Experience:An experiement combining mangoes and cannabis
  • Experience:BK-2C-B - Various experiences
  • Experience:DXM and Cannabis: 100mg - Unexpected Strong Trip
  • Experience:Datura and nicotine smoked - 4 and ~15 hits; was actually quite pleasant
  • Experience:Diazepam (20/10mg, Oral) - Comfortably Drunk_-_Comfortably_Drunk.md)
  • Experience:Kratom + Phenibut + Cannabis - Warm Bliss
  • Experience:MXE: 37.5 mg - Calm and Cloudy Bliss
  • Experience:Mushrooms (~0.5 g) - Autonomous Voice_-_Autonomous_Voice.md)
  • Experience:Nightmare flipping
  • Experience:Psilocybin Mushroom (0.16 g, Oral) - Dosage Independent Intensity_-_Dosage_Independent_Intensity.md)
  • Experience:Zopiclone hppd?
  • Experience:~150mg MDA(oral) - a case of mistaken identity_-_a_case_of_mistaken_identity.md)

另见

外部链接

参考文献

  1. ↑ anxiolysis, National Cancer Institute 
  2. ↑ Gordon, Joshua A. (2002). "Anxiolytic drug targets: beyond the usual suspects". Journal of Clinical Investigation. 110 (7): 915–917. doi:10.1172/JCI0216846. ISSN 0021-9738. 
  3. ↑ Tyrer, P. (27 February 1988). "Prescribing psychotropic drugs in general practice". BMJ. 296 (6622): 588–589. doi:10.1136/bmj.296.6622.588. 
  4. ↑ Lydiard, R. B. (2003). "The role of GABA in anxiety disorders". The Journal of Clinical Psychiatry. 64 Suppl 3: 21–27. ISSN 0160-6689. 
  5. ↑ Gauthier, Isabelle; Nuss, Philippe (2015). "Anxiety disorders and GABA neurotransmission: a disturbance of modulation". Neuropsychiatric Disease and Treatment: 165. doi:10.2147/NDT.S58841. ISSN 1178-2021. 
  6. ↑ Wood, Alastair J.J.; Shader, Richard I.; Greenblatt, David J. (1993). "Use of Benzodiazepines in Anxiety Disorders". New England Journal of Medicine. 328 (19): 1398–1405. doi:10.1056/NEJM199305133281907. ISSN 0028-4793. 
  7. ↑ Smith, J. P., Randall, C. L. (2012). "Anxiety and alcohol use disorders: comorbidity and treatment considerations". Alcohol Research: Current Reviews. 34 (4): 414–431. ISSN 2168-3492. 
  8. ↑ Schmidt-Mutter, Catherine; Pain, Laure; Sandner, Guy; Gobaille, Serge; Maitre, Michel (1998). "The anxiolytic effect of γ-hydroxybutyrate in the elevated plus maze is reversed by the benzodiazepine receptor antagonist, flumazenil". European Journal of Pharmacology. 342 (1): 21–27. doi:10.1016/S0014-2999(97)01503-3. ISSN 0014-2999. 
  9. ↑ Pollack, Mark H.; Matthews, John; Scott, Erin L. (1998). "Gabapentin as a Potential Treatment for Anxiety Disorders". American Journal of Psychiatry. 155 (7): 992–993. doi:10.1176/ajp.155.7.992. ISSN 0002-953X. 
  10. ↑ Blessing, Esther M.; Steenkamp, Maria M.; Manzanares, Jorge; Marmar, Charles R. (2015). "Cannabidiol as a Potential Treatment for Anxiety Disorders". Neurotherapeutics. 12 (4): 825–836. doi:10.1007/s13311-015-0387-1. ISSN 1933-7213. 
  11. ↑ Irwin, Scott A.; Iglewicz, Alana (2010). "Oral Ketamine for the Rapid Treatment of Depression and Anxiety in Patients Receiving Hospice Care". Journal of Palliative Medicine. 13 (7): 903–908. doi:10.1089/jpm.2010.9808. ISSN 1096-6218. 
  12. ↑ (PDF) https://www.regionkronoberg.se/contentassets/7fd21479ae564476a1b8639e9519ede9/diazepam-hameln.pdf.  Missing or empty |title= (help"))