4位取代色胺综合
迷幻剂
4位取代色胺1
数据为Ki,单位为nm
5-HT受体
| Drug | 5-HT₁A | 5-HT₁B | 5-HT₁D | 5-HT₁E | 5-HT₂A | 5-HT₂B | 5-HT₂C | 5-HT₅ₐ | 5-HT₆ | 5-HT₇ |
|---|---|---|---|---|---|---|---|---|---|---|
| 4-HO-DMT | 396 | 2,410 | 274 | 229 | 336 | 17 | 228 | 325 | 54 | 73 |
| 4-HO-MET | 135 | 331 | 197 | 161 | 177 | 12 | 164 | 304 | 70 | 60 |
| 4-AcO-MET | 950 | 960 | 667 | 500 | 514 | 17 | 370 | - | 345 | 310 |
| 4-HO-DET | 414 | 2,242 | 585 | 568 | 400 | 73 | 436 | 1,429 | 230 | 826 |
| 4-AcO-DET | - | 3,817 | 445 | 1,162 | - | 53 | 875 | - | 860 | 1,680 |
| 4-HO-MPT | 106 | 224 | 170 | 246 | 114 | 8 | 150 | 664 | 48 | 99 |
| 4-AcO-MPT | - | 9,108 | 1,900 | - | 830 | 22 | 694 | 1,805 | 383 | 220 |
| 4-HO-EPT | 163 | 1,097 | 644 | 591 | 546 | 62 | 1,272 | 1,576 | 284 | 438 |
| 4-AcO-EPT | - | 9,259 | 1,674 | 2,225 | 2,459 | 43 | 967 | - | 1,787 | 321 |
| 4-HO-DiPT | - | - | 1,860 | - | 922 | 85 | - | - | - | - |
| 4-HO-MALT | 402 | 1,500 | 159 | 165 | 357 | 20 | 392 | 492 | 195 | 179 |
| 4-AcO-MALT | 1,141 | - | 699 | 775 | 1,006 | 9 | 1,556 | 1,246 | 241 | 582 |
| 4-HO-DALT | 131 | 978 | 432 | 367 | 452 | 63 | 1,550 | 2,966 | 578 | 454 |
| 4-AcO-DALT | 582 | 2,689 | 2,099 | 2,116 | 958 | 137 | 824 | - | 479 | 406 |
| Drug | H₁ | KOR | NR2B | Sigma 1 | Sigma 2 | α₂A | α₂B | α₂C | SERT | DAT | M₄ | H₂ | D₂ | D₃ | D₄ | D₅ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4-PrO-DMT | 1,481 | 4,745 | 6,250 | - | 1,349 | - | - | - | - | - | - | - | - | - | - | - |
| 4-HO-MET | 483 | - | >10,000 | - | - | 1,666 | - | - | 1,830 | - | - | - | - | - | - | - |
| 4-AcO-MET | 1,720 | - | - | 7,077 | - | - | 1,681 | - | - | - | - | - | - | 1,371 | - | - |
| 4-HO-DET | 1,079 | - | 8,720 | - | 3,026 | - | - | - | 1,800 | - | - | 9,984 | - | - | - | - |
| 4-AcO-DET | - | - | 2,936 | - | - | 1,965 | 1,095 | - | - | - | - | - | 1,534 | - | - | - |
| 4-HO-MPT | 92 | - | 3,658 | 891 | 1,166 | 3,625 | 1,844 | - | 910 | - | - | - | - | 921 | - | - |
| 4-AcO-MPT | 493 | - | - | 1,512 | - | 1,300 | 453 | 1,447 | - | - | - | - | - | - | - | - |
| 4-HO-EPT | 406 | - | 5,947 | 1,400 | 1,773 | 2,073 | - | - | 1,257 | - | - | - | 3,010 | 985 | - | - |
| 4-AcO-EPT | 1,024 | - | 8,111 | - | 3,497 | 1,135 | 274 | 1,329 | - | - | - | - | - | - | - | - |
| 4-HO-DiPT | - | - | - | 1,063 | 2,215 | - | - | - | 816 | >10,000 | 1,725 | - | - | - | - | - |
| 4-HO-MALT | 815 | - | NT | 1,413 | 2,525 | 535 | - | - | 355 | - | - | 1,448 | - | - | - | >10,000 |
| 4-AcO-MALT | 2,603 | - | NT | 3,471 | - | 387 | 1,169 | - | - | - | - | - | - | - | 578 | - |
| 4-HO-DALT | 355 | - | - | 1,846 | 1,770 | 2,670 | 2,084 | 2,280 | 657 | - | 5,280 | - | >10,000 | 578 | 2,256 | - |
| 4-AcO-DALT | 874 | - | - | - | 4,190 | 482 | 214 | 803 | - | - | - | - | 4,522 | 1,907 | - | - |
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ACS Pharmacol. Transl. Sci. 2023, 6, 567−577 https://pubs.acs.org/doi/10.1021/acsptsci.2c00222 ↩